Tumor Necrosis Factor Inhibitor Drugs Market (By Product: Humira, Enbrel, Remicade, Simponi, Cimzia; By Application: Autoimmune Disease, Psoriasis, Psoriatic Arthritis, Crohn’s Disease, Ulcerative Colitis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis, Hidradenitis Suppurativa, Others, By Sales Channel: Hospital pharmacies, Specialty pharmacies, Online pharmacies) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2024-2033
The global tumor necrosis factor inhibitor drugs market size was valued at USD 42.07 billion in 2023 and is projected to reach around USD 50.63 billion by 2033, registering a CAGR of 1.87% from 2024 to 2033. The need for tumor necrosis factor (TNF) inhibitor medications is being driven by the rising incidence of autoimmune illnesses around the globe.
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TNF inhibitors, with yearly sales in the billions, have been a significant source of income for pharmaceutical corporations. For a number of years, Humira (adalimumab) was the best-selling medication in the world, bringing in billions of dollars in sales every year. The introduction of biosimilars, which are comparable copies of licensed biologic medications, has boosted competition in the tumor necrosis factor inhibitor drugs market.
Biosimilars may result in financial benefits for patients and healthcare systems, which would boost their uptake. TNF inhibitors have demonstrated promise in treating inflammatory bowel illness, including Crohn's disease and ulcerative colitis, psoriasis, psoriatic arthritis, and ankylosing spondylitis, in addition to their well-established usage in rheumatic disorders. Prospective combination treatments and novel indications are still being investigated in ongoing research. These include injection site responses, greater susceptibility to infections, and, in certain situations, an increased chance of developing certain cancers.
Although TNF inhibitors have completely changed the way autoimmune disorders are treated, they are not without dangers and drawbacks. The approval and marketing of TNF inhibitors and biosimilars are strictly regulated by regulatory agencies such as the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). Changes in labeling and other regulatory actions can have a big effect on how the market works. Concerns have also been expressed about availability and cost, specifically in relation to how affordable these biological medicines are for individuals and healthcare systems.
Report Coverage | Details |
Global Market Size in 2023 | USD 42.07 Billion |
Global Market Size in 2024 | USD 42.86 Billion |
Global Market Size by 2033 | USD 50.63 Billion |
Growth Rate from 2024 to 2033 | CAGR of 1.87% |
Largest Market | North America |
Base Year | 2023 |
Forecast Period | 2024 to 2033 |
2024 to 2033 | By Product, By Product, and By Sales Channel |
Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Driver: Efficiency in treating chronic diseases
An essential component of healthcare management is the effectiveness of treatment for chronic illnesses in the market for tumor necrosis factor (TNF) inhibitor drugs. TNF inhibitors are drugs that are frequently used to treat autoimmune conditions such as ulcerative colitis, ankylosing spondylitis, psoriasis, rheumatoid arthritis, and Crohn's disease. TNF inhibitors function by reducing the inflammatory cytokine tumor necrosis factor-alpha's activity. Effective therapy should significantly reduce symptoms of autoimmune illnesses, including skin lesions, stiffness, inflammation, and gastrointestinal problems, in addition to joint pain and stiffness. The patient's quality of life gains should be taken into consideration when assessing the effectiveness of a treatment plan. This covers elements including overall treatment satisfaction, psychological well-being, physical function, and capacity to carry out everyday tasks.
Restraint: Development of antibodies
A key component of biopharmaceutical innovation in the market for tumor necrosis factor (TNF) inhibitor medications has been the creation of antibodies. A class of drugs known as TNF inhibitors work by inhibiting the function of a cytokine called tumor necrosis factor-alpha (TNF-α), which is involved in systemic inflammation. They are mostly used to treat autoimmune conditions such as ankylosing spondylitis, psoriasis, rheumatoid arthritis, and Crohn's disease. The initial class of TNF inhibitors comprised monoclonal antibodies (mAbs) that selectively targeted TNF-α. These antibodies are designed to attach to TNF-α and stop it from doing its job, which lowers inflammation and the signs and symptoms of illness. Other TNF inhibitors, such as TNF receptor fusion proteins like etanercept, have been developed in addition to monoclonal antibodies.
Opportunity: Personalized medicine
Tumor necrosis factor (TNF) inhibitor medications are essential in the treatment of conditions like psoriasis, Crohn's disease, and rheumatoid arthritis (RA), and personalized medicine has revolutionized many facets of healthcare. Biologic drugs called TNF inhibitors can help control inflammation and treat symptoms of diseases including Crohn's disease and RA. Genetic variants that may affect a patient's reaction to TNF inhibitor medications can be found through genetic testing. By using this information, doctors can choose the right drug and dosage for each patient, increasing effectiveness and reducing side effects. Healthcare professionals can evaluate each patient's unique risks—such as infections or infusion reactions—related to TNF inhibitor medication thanks to personalized medicine.
The Humira segment led the tumor necrosis factor inhibitor drugs market in 2023 and is projected to maintain its position during the forecast period. Historically, Humira (adalimumab) has been one of the top medications in the market for TNF inhibitors. Many autoimmune illnesses, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, and plaque psoriasis, are treated with TNF inhibitors like Humira. Humira has been one of the top-selling medications in the world for a number of years, thanks to AbbVie, the pharmaceutical firm that created it. But with the advent of biosimilars—similar but distinct versions of biologic medications like Humira—the market for TNF inhibitors has grown more competitive. Compared to original branded medications, biosimilars are more reasonably priced.
In the tumor necrosis factor inhibitor drugs market, the Enbrel segment is also expected to grow at the fastest CAGR in the upcoming years. Enbrel, also known as etanercept, is a well-known medication within the tumor necrosis factor inhibitor family. This particular class of medications is used to treat autoimmune illnesses, including juvenile idiopathic arthritis, rheumatoid arthritis, psoriasis, and psoriatic arthritis. It functions by preventing the body's production of TNF, a chemical that causes inflammation. Along with other TNF inhibitors such as Humira (adalimumab), Remicade (infliximab), Simponi (golimumab), and Cimzia (certolizumab pegol), Enbrel has historically been one of the most popular drugs. These medications are often used and have made a substantial difference in the management of autoimmune disorders. The market for TNF inhibitor medications continues to be dominated by Enbrel, in part because of its well-established safety and effectiveness profiles.
The autoimmune disease segment led the tumor necrosis factor inhibitor drugs market globally in 2023. A class of drugs known as tumor necrosis factor inhibitors is frequently prescribed to treat autoimmune conditions such as Crohn's disease, ulcerative colitis, psoriasis, rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. These medications function by preventing the body's natural production of TNF, which is an inflammatory agent. The ironic side effect of TNF inhibitor medication, the emergence of autoimmune illnesses, is another crucial factor to take into account. While these drugs are intended to treat autoimmune disorders, there is a chance that they will aggravate pre-existing autoimmune diseases or cause new ones to arise. Ultimately, even though TNF inhibitors have transformed the way autoimmune disorders are treated and have greatly benefited a large number of people, healthcare professionals still need to carefully consider the advantages and disadvantages of the prescription of these drugs.
In the tumor necrosis factor inhibitor drugs market, the psoriasis segment is expected to expand notably during the forecast period. Inflammation is a hallmark of both psoriasis and psoriatic arthritis, two chronic autoimmune illnesses that can cause issues with the skin and joints. The need for efficient treatment alternatives has increased due to the expanding global prevalence of psoriasis and psoriatic arthritis. TNF inhibitors belong to the larger class of biological treatments, which have made great strides in the last several years. Patients now have more therapy options thanks to the introduction of newer TNF inhibitors that have better safety and efficacy characteristics on the market. Increased accessibility to healthcare, particularly in developing nations, has further fueled the market for TNF inhibitor medications. The market keeps growing as more people have access to these drugs.
The hospital pharmacies segment dominated the tumor necrosis factor inhibitor drugs market in 2023. Since tumor necrosis factor inhibitor medications are mostly used to treat autoimmune disorders such as rheumatoid arthritis, psoriasis, Crohn's disease, and ankylosing spondylitis, hospital pharmacies are important players in the market for these medications. Hospital pharmacies are in charge of obtaining, storing, preparing, and giving patients TNF inhibitors, which are frequently given as injections or infusions. Purchasing TNF inhibitor medications from manufacturers or pharmaceutical suppliers is the responsibility of hospital pharmacists. Hospital pharmacy ensures that inventory is managed properly and that pharmaceuticals are not allowed to spoil or run out. TNF inhibitor medications are given to patients by hospital pharmacy in accordance with doctor's orders.
In the tumor necrosis factor inhibitor drugs market, the specialty pharmacies segment is expected to obtain a substantial market share during the forecast period. Tumor necrosis factor inhibitor medications, which are frequently used to treat autoimmune disorders such as rheumatoid arthritis, psoriasis, Crohn's disease, and ankylosing spondylitis, are distributed and managed largely by specialty pharmacies. Patients who participate in these programs receive information and support in order to understand better their prescription regimen, possible adverse effects, and the significance of adherence. To ensure that patients receive TNF Inhibitor medications on time and to handle any concerns related to insurance or coverage, specialty pharmacies frequently collaborate closely with medical professionals and insurance providers. Clinical monitoring services, such as laboratory testing and assistance with disease management, may be provided by specialty pharmacies.
North America held the largest share of the global tumor necrosis factor inhibitor drugs market in 2023 and is expected to grow further during the forecast period. This is mostly due to the rise in autoimmune illnesses such as psoriasis, ulcerative colitis, rheumatoid arthritis, and Crohn's disease. TNF is a chemical that can produce inflammation and contribute to autoimmune illnesses; as such, TNF inhibitors suppress the immune system by preventing TNF from doing its job. The market for TNF inhibitor medications is anticipated to expand in North America as a result of aging populations, an increase in autoimmune disease incidence, and escalating healthcare costs. Furthermore, the market is anticipated to continue growing due to developments in biotechnology and the creation of innovative treatments.
In the tumor necrosis factor inhibitor drugs market, Asia Pacific is also expected to gain a significant share in the upcoming years. Over the past few years, the area has seen steady growth in the market for medications that block the tumor necrosis factor (TNF). A class of drugs known as TNF inhibitors inhibits the function of a cell signaling protein called tumor necrosis factor-alpha (TNF-α), which is involved in inflammation. In Asia Pacific, autoimmune illnesses like psoriasis, rheumatoid arthritis, and inflammatory bowel disorders are becoming more common. The demand for these medications is fueled by the widespread use of TNF inhibitors in the treatment of various illnesses. Spending on healthcare has increased as a result of economic expansion in several Asia Pacific nations. As a result, more patients may now afford pricey biologic medications like TNF inhibitors.
Segment Covered in the Report
By Product
By Application
By Sales Channel
By Geography
Chapter 1. Introduction
1.1. Research Objective
1.2. Scope of the Study
1.3. Definition
Chapter 2. Research Methodology
2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations
Chapter 3. Executive Summary
3.1. Market Snapshot
Chapter 4. Market Variables and Scope
4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis
Chapter 5. COVID 19 Impact on Tumor Necrosis Factor Inhibitor Drugs Market
5.1. COVID-19 Landscape: Tumor Necrosis Factor Inhibitor Drugs Industry Impact
5.2. COVID 19 - Impact Assessment for the Industry
5.3. COVID 19 Impact: Global Major Government Policy
5.4. Market Trends and Opportunities in the COVID-19 Landscape
Chapter 6. Market Dynamics Analysis and Trends
6.1. Market Dynamics
6.1.1. Market Drivers
6.1.2. Market Restraints
6.1.3. Market Opportunities
6.2. Porter’s Five Forces Analysis
6.2.1. Bargaining power of suppliers
6.2.2. Bargaining power of buyers
6.2.3. Threat of substitute
6.2.4. Threat of new entrants
6.2.5. Degree of competition
Chapter 7. Competitive Landscape
7.1.1. Company Market Share/Positioning Analysis
7.1.2. Key Strategies Adopted by Players
7.1.3. Vendor Landscape
7.1.3.1. List of Suppliers
7.1.3.2. List of Buyers
Chapter 8. Global Tumor Necrosis Factor Inhibitor Drugs Market, By Product
8.1. Tumor Necrosis Factor Inhibitor Drugs Market Revenue and Volume, by Product, 2024-2033
8.1.1 Humira
8.1.1.1. Market Revenue and Volume Forecast (2021-2033)
8.1.2. Enbrel
8.1.2.1. Market Revenue and Volume Forecast (2021-2033)
8.1.3. Remicade
8.1.3.1. Market Revenue and Volume Forecast (2021-2033)
8.1.4. Simponi
8.1.4.1. Market Revenue and Volume Forecast (2021-2033)
8.1.5. Cimzia
8.1.5.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 9. Global Tumor Necrosis Factor Inhibitor Drugs Market, By Application
9.1. Tumor Necrosis Factor Inhibitor Drugs Market Revenue and Volume, by Application, 2024-2033
9.1.1. Autoimmune disease
9.1.1.1. Market Revenue and Volume Forecast (2021-2033)
9.1.2. Psoriasis
9.1.2.1. Market Revenue and Volume Forecast (2021-2033)
9.1.3. Psoriatic arthritis
9.1.3.1. Market Revenue and Volume Forecast (2021-2033)
9.1.4. Crohn’s disease
9.1.4.1. Market Revenue and Volume Forecast (2021-2033)
9.1.5. Ulcerative Colitis
9.1.5.1. Market Revenue and Volume Forecast (2021-2033)
9.1.6. Ankylosing spondylitis
9.1.6.1. Market Revenue and Volume Forecast (2021-2033)
9.1.7. Juvenile idiopathic arthritis
9.1.7.1. Market Revenue and Volume Forecast (2021-2033)
9.1.7. Hidradenitis suppurativa
9.1.7.1. Market Revenue and Volume Forecast (2021-2033)
9.1.7. Others
9.1.5.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 10. Global Tumor Necrosis Factor Inhibitor Drugs Market, By Sales Channel
10.1. Tumor Necrosis Factor Inhibitor Drugs Market Revenue and Volume, by Sales Channel, 2024-2033
10.1.1. Hospital Pharmacies
10.1.1.1. Market Revenue and Volume Forecast (2021-2033)
10.1.2. Specialty Pharmacies
10.1.2.1. Market Revenue and Volume Forecast (2021-2033)
10.1.3. Specialty Pharmacies
10.1.3.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 11. Global Tumor Necrosis Factor Inhibitor Drugs Market, Regional Estimates and Trend Forecast
11.1. North America
11.1.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.1.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.1.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.1.4. U.S.
11.1.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.1.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.1.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.1.5. Rest of North America
11.1.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.1.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.1.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.2. Europe
11.2.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.2.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.2.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.2.4. UK
11.2.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.2.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.2.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.2.5. Germany
11.2.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.2.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.2.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.2.6. France
11.2.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.2.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.2.6.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.2.7. Rest of Europe
11.2.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.2.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.2.7.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.3. APAC
11.3.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.3.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.3.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.3.4. India
11.3.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.3.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.3.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.3.5. China
11.3.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.3.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.3.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.3.6. Japan
11.3.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.3.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.3.6.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.3.7. Rest of APAC
11.3.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.3.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.3.7.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.4. MEA
11.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.4.4. GCC
11.4.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.4.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.4.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.4.5. North Africa
11.4.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.4.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.4.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.4.6. South Africa
11.4.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.4.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.4.6.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.4.7. Rest of MEA
11.4.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.4.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.4.7.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.5. Latin America
11.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.5.4. Brazil
11.5.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.5.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.5.4.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
11.5.5. Rest of LATAM
11.5.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
11.5.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
11.5.5.3. Market Revenue and Volume Forecast, by Sales Channel (2021-2033)
Chapter 12. Company Profiles
12.1. UCB Inc.
12.1.1. Company Overview
12.1.2. Product Offerings
12.1.3. Financial Performance
12.1.4. Recent Initiatives
12.2. Pfizer Inc
12.2.1. Company Overview
12.2.2. Product Offerings
12.2.3. Financial Performance
12.2.4. Recent Initiatives
12.3. Johnson & Johnson
12.3.1. Company Overview
12.3.2. Product Offerings
12.3.3. Financial Performance
12.3.4. Recent Initiatives
12.4. Amgen Inc.
12.4.1. Company Overview
12.4.2. Product Offerings
12.4.3. Financial Performance
12.4.4. Recent Initiatives
12.5. Abbvie
12.5.1. Company Overview
12.5.2. Product Offerings
12.5.3. Financial Performance
12.5.4. Recent Initiatives
Chapter 13. Research Methodology
13.1. Primary Research
13.2. Secondary Research
13.3. Assumptions
Chapter 14. Appendix
14.1. About Us
14.2. Glossary of Terms
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