Peptide Synthesis Market Size, Share, and Trends 2024 to 2033

Peptide Synthesis Market Size and Forecast

The global peptide synthesis market size was USD 581.06 million in 2023, calculated at USD 627.72 million in 2024 and is expected to reach around USD 1257.95 million by 2033, expanding at a CAGR of 8.03% from 2024 to 2033. The benefits of peptide synthesis include it helps to design new vaccines, drugs, and enzymes and is also used to prepare enzyme binding sites, epitope-scientific antibodies, and map antibody epitopes. These factors help to the growth of the market. The North America peptide synthesis market size reached USD 214.99 million in 2023.

Peptide Synthesis Market Key Takeaways

• North America dominated the peptide synthesis market with the largest revenue share of 37% in 2023.
• Asia Pacific is estimated to be the fastest-growing during the forecast period of 2024-2033.
• By product, the reagents & consumables segment dominated the market in 2023.
• By product, the peptide synthesis equipment segment is anticipated to be the fastest-growing during the forecast period.
• By technology, the liquid phase peptide synthesis (LPPS) segment dominated the market in 2023.
• With the help of technology, the solid phase peptide synthesis (SPPS) segment is estimated to be the fastest-growing during the forecast period.
• By application, the therapeutics segment dominated the market in 2023.
• By application, the diagnosis segment is expected to be the fastest-growing during the forecast period.
• By end-use, the pharmaceutical & biotechnology companies segment dominated the peptide synthesis market in 2023.
• By end-use, the contract development & manufacturing organization (CMO)/contract research organization (CRO) segment is anticipated to be the fastest-growing during the forecast period.

U.S. Peptide Synthesis Market Size and Growth 2024 to 2033

The U.S. peptide synthesis market size was exhibited at USD 150.49 million in 2023 and is projected to be worth around USD 332.57 million by 2033, poised to grow at a CAGR of 8.25% from 2024 to 2033.

North America dominated the peptide synthesis market in 2023. Increased focus on peptide-based drugs and rising awareness about peptide synthesis technologies help the market growth in the North American region. The United States is the leading country for the growth of the market in the North American region. In the United States, Bachem is a leading company specializing in the manufacture and development of oligonucleotides and peptides.

• In September 2023, an increased commercial peptide production capacity with newly upgraded facilities in the US at its Colorado site was inaugurated by a specialist in APIs, drugs, excipients products, and packaging services, CDMO Corden Pharma.

Asia Pacific is estimated to be the fastest-growing during the forecast period of 2024-2033. Increasing incidences of chronic disease conditions, rising healthcare spending, increased awareness of new peptide-based treatments, and increased investment by market players help the growth of the peptide synthesis market in the Asia Pacific region. China is the leading country for the growth of the market in the Asia Pacific region.

• In January 2024, two new peptide manufacturing plants, one at its Changzhou facility and another in China at the new Taixing site, launched by a global company, WuXi AppTec, that provides a broad portfolio of R&D and manufacturing services that allow companies in medical devices, and pharmaceuticals, and biotech industries to advance the development and deliver treatments to patients. This remarkable expansion increased the company's SPPS (Solid Phase Peptide Synthesis) and addressed the surging global demand for peptide therapeutics.

Market Overview

The peptide synthesis market deals with pharmaceutical & biotechnology companies, academic research & institutes, and CRO/CMO for the applications of therapeutics, diagnosis, and research. Peptide synthesis is the production of compounds and peptides, where multiple amino acids are linked by amide bonds. The benefits of peptide synthesis include customization and flexibility, scale and efficiency, unnatural amino acids, D-proteins, and industrial production. The applications include helping with the identification and characterization of proteins, making easy protein expression services or protein functions, and creating epitope-specific antibodies against pathogenic proteins. These factors help to the growth of the market.

Peptide Synthesis Market Growth Factors

• The peptide synthesis benefits include customization and flexibility, scale and efficiency, unnatural amino acids, D-proteins, and industrial production that helps the growth of the market.
• The applications of peptide synthesis include helping with the identification and characterization of proteins.
• It also helps in the study of protein expression services or protein functions, which helps the growth of the market.
• It also helps to create epitopes-specific antibodies against pathogenic proteins which helps the growth of the peptide synthesis market.

Market Scope

Market Dynamics

Driver

Increased use of peptides in pharmaceutical treatments

The benefits of developing and using pharmaceutical peptides include a lower production amount and lower cell prices. Peptides have good membrane penetration ability, and oral administration helps with easy delivery to patients. The benefits of peptide drugs include having fewer side effects and being safer because their byproducts are amino acids than other drugs. Peptides are highly used in pharmaceutical treatments due to their beneficial properties, which include antithrombic (or anticlotting), antioxidant, and antimicrobial properties. In pharmaceuticals, peptides are referred to as therapeutic peptides and are commonly used for the treatment of diseases. In pharmaceutical treatments, lab-processed peptides are growth hormones and human insulin. Both of these are life-saving for people living with specific conditions. These factors help the growth of the peptide synthesis market.

Restraint

Challenges in peptide synthesis

The main challenge in peptide synthesis includes the development of efficient and sustainable catalytic methods. SPPS (Solid phase peptide synthesis) depends on the effective amide bond formation between amino acids. Limitations of peptide synthesis include it requires the use of a large amount of peptide, a time-consuming process, labor-intensive purification steps for each intermediate compound to make the solution phase, and labor-intensive, which finally yields a limited number of desired products. The solid phase peptide synthesis requires high temperatures and strict reaction conditions. This requires the use of specialized reaction conditions and equipment like high-temperature atmospheres and high-temperature furnaces. These factors can restrict the growth of the peptide synthesis market.

Opportunity

Future scope of the peptide synthesis

In the future, peptide synthesis will find an increased use in treating type-2 diabetes, obesity, and metabolic syndromes. Increasing use of cyclic peptides, synthesizing long peptides, microwave-assisted peptide synthesis, and solid phase synthesis. In medicines, peptides are used because they include cell-penetrating, multifunctional peptide drug conjugates, and technologies focusing on alternative routes of administration. Peptides offer growth opportunities as future therapeutics. These factors help the growth of the peptide synthesis market.

Product Insights

The reagents & consumables segment dominated the market in 2023. Peptides are highly used for reagents & consumables because of their benefits, including the prevention of the formation of blood clots, killing microbes, acting as antioxidants and antitumors, reducing inflammation, lowering blood pressure, and improving immune functions. It also helps to support bone health and promote muscle growth due to its wound healing and anti-aging effects properties. The most important advantage of peptide reagents & consumables is helping to reduce wrinkles and fine lines, improve skin elasticity, and ability to stimulate collagen production in the skin. These factors help the growth of the reagents & consumables segment and contribute to the growth of the peptide synthesis market.

The peptide synthesis equipment segment is expected to be the fastest-growing during the forecast period. In peptide synthesis, peptide synthesis equipment plays an important role. The manual solid-phase peptide synthesis is carried out with the help of standard laboratory glass wares like sintered glass funnels, round bottom flasks, etc. It also includes overhead mechanical stirrers, wrist action shakers, or orbital shakers. The applications of peptide synthesis equipment include food preservation, medical visualization, peptide therapeutic, the production of proteins, and the production of antibodies. These factors help the growth of the peptide synthesis equipment and contribute to the growth of the peptide synthesis market.

Technology Insights

The liquid phase peptide synthesis (LPPS) segment dominated the market in 2023. The benefits of the liquid phase peptide synthesis (LPPS) segment include flexibility in chemistry for the choice of chemical reagents and reactions, which helps with the high range of coupling chemistries and functional group manipulations. It also includes facilitating modifications and labeling, reduction of side reactions, scale-up capabilities, and high purity and yield. These factors help the growth of the liquid phase peptide synthesis (LPPS) segment and contribute to the growth of the peptide synthesis market.

The solid phase peptide synthesis (SPPS) segment is anticipated to be the fastest-growing during the forecast period. Solid-phase peptide synthesis (SPPS) has benefits that include high efficiency, increased speed, and simplicity. The use of excess reagents in this reaction may be driven to completion and high yields. Building blocks are protected in this method for all reactive functional groups. These factors help the growth of the solid phase peptide synthesis (SPPS) segment and contribute to the growth of the peptide synthesis market.

Application Insights

The therapeutics segment dominated the market in 2023. Peptide synthesis advances and their therapeutics exploration have opened the direction for their use in tissue engineering, gene therapy, molecular and biosensing recognition, nano-delivery systems, drug delivery, and disease diagnosis. Peptide has high tunable and high purity profile properties, which are used in the discovery of non-imaging and imaging-based diagnostics agents like positron emission, peptide-based ELISA, and single-photon emission computed tomography (SPECT).

Peptides are used in drug development to treat many pathologies, including cancer, microbial infections, and obesity, as well as to improve cell-penetrating properties and develop cell-targeting platforms. Chemical peptide synthesis development by SPPS accelerated the therapeutics peptide development. Some recombinant peptide drugs like teriparatide and oxytocin use chemical synthesis for the production of (API) active pharmaceutical ingredients. These factors help the growth of the therapeutics segment and contribute to the growth of the peptide synthesis market.

The diagnosis segment is anticipated to be the fastest-growing during the forecast period. The use of peptide synthesis in diagnosis increased to get accurate and specific information about disease due to their ability to get modified chemically and high purity profile. Peptide synthesis is used for imaging or non-imaging-based diagnostics. In non-imaging-based diagnostics, peptide synthesis is used, and techniques like LC-MS/MS or microarray are used for direct analysis of biofluids, point-of-care testing, and enzyme-linked immunosorbent assay (ELISA). In clinical and scientific research, peptide synthesis is highly used for diagnostics applications; for diagnosis of infectious and non-infectious diseases, peptide-based products are used. These factors help to the growth of the diagnosis segment and contribute to the growth of the peptide synthesis market.

End-use Insights

The pharmaceutical & biotechnology companies segment dominated the peptide synthesis market in 2023. In pharmaceutical & biotechnology companies, the use of peptide synthesis plays an important role. In pharmaceutical manufacturing, chemical, and recombinant peptide synthesis are the two basic processes for amino acids, which offer many benefits for different applications. In pharmaceuticals, peptides are referred to as therapeutic peptides. Peptide synthesis is used to design new vaccines, drugs, and enzymes, and to prepare enzyme binding sites, map antibody epitopes, and epitope-specific antibodies. In pharmaceutical & biotechnology companies, peptide synthesis is used in research, drug development, and diagnostics purposes. These factors helped the growth of the pharmaceutical & biotechnology companies segment and contributed to the growth of the market.

The contract development & manufacturing organization (CMO)/contract research organization (CRO) segment is expected to be the fastest-growing during the forecast period. CMO takes preformulated drugs, which are developed by CRO, and manufactures them on a larger scale. CRO companies provide clinical trial services for the medical device, pharmaceutical, and biotechnology industries. The benefits of CRO & CMO include it helps to understand and segment users to guide them towards purchasing the services and products that best meet their needs. CRO provides a broad spectrum of services, including clinical research, laboratory & lifecycle management, and drug development. These factors help the growth of the contract development & manufacturing organization (CMO)/ contract research organization (CRO) segment and contribute to the growth of the peptide synthesis market.

Recent Developments

• In April 2022, the Liberty 2.0 instrumentation line of automated microwave peptide synthesizers was launched by the CEM Corporation.
• In March 2024, a leading global pharmaceutical company, Aurisco Pharmaceutical, announced an investment in a cGMP peptide manufacturing facility for GLP-1 peptides in Yangzhou, China, at the company’s USFDA-inspected site.
• In May 2024, a new Activo-Darwin Semi-Automated Peptide Synthesizer, a cutting edge launched by Activotec Ltd., designed for very high-quality peptide synthesis. The Activo-Darwin tool is very easy, affordable, and flexible for peptide synthesis.

Peptide Synthesis Market Companies

• Novo Nordisk A/S
• MP Biomedicals
• Lonza
• PuroSynth
• Syngene
• Polypeptide Group
• Creative Diagnostics
• Thermo Fischer Scientific, Inc.
• CEM Corporation
• Biotage
• Bachem Holdings AG
• Merck KGaA
• GenScript Biotech Corporation
• Kaneka Corporation

Segments Covered in the Report

By Product

• Equipment
  • Peptide Synthesizers
  • Lyophilizers
  • Chromatography Equipment
  • Others
• Reagents & Consumables
• Other

By Technology

• Solid Phase Peptide Synthesis (SPPS)
• Liquid Phase Peptide Synthesis (LPPS)
• Hybrid Technology

By Application

• Therapeutics
  • Cancer
  • Metabolic
  • Cardiovascular Disorder
  • Respiratory
  • GIT (Gastrointestinal Disorders)
  • Infectious Diseases
  • Pain
  • Dermatology
  • CNS
  • Renal
  • Others
• Diagnosis
• Research

By End-use

• Pharmaceutical & Biotechnology Companies
• Contract Development & Manufacturing Organization/Contract Research Organization
• Academic Research & Institutes

By Geography

• North America
• Asia Pacific
• Europe
• Latin America
• Middle East & Africa