Vaccine Adjuvants Market Size, Share and Trends 2024 to 2034

The global vaccine adjuvants market size is calculated at USD 1.73 billion in 2024, grew to USD 1.77 billion in 2025 and is predicted to hit around USD 2.18 billion by 2034, expanding at a CAGR of 2.33% between 2024 and 2034. The North America vaccine adjuvants market size is evaluated at USD 730 million in 2024 and is expected to grow at a CAGR of 2.38% during the forecast year.

  • Last Updated : 13 Dec 2024
  • Report Code : 5349
  • Category : Healthcare

Vaccine Adjuvants Market Size and Forecast 2024 to 2034

The global vaccine adjuvants market size accounted for USD 1.73 billion in 2024 and is expected to exceed around USD 2.18 billion by 2034, growing at a CAGR of 2.33% from 2024 to 2034. The increasing adoption of the vaccine adjuvants market is as it is an essential component of vaccines in enhancing both immune response and efficacy.

Vaccine Adjuvants Market Size 2024 to 2034

Vaccine Adjuvants Market Key Takeaways

  • North America dominated the global market with the largest market share of 42% in 2023.
  • Middle East and Africa are anticipated to register significant growth during the forecast period. 
  • By type, the particulate segment captured the biggest market share in 2023.
  • By type, the pathogen segment shows notable growth during the forecast period.
  • By administration, the intramuscular segment contributed the highest market share of 34% in 2023.
  • By administration, the intradermal segment will show notable growth during the forecast period.
  • By application, the infectious disease segment generated the major market share in 2023.
  • By application, the cancer segment is anticipated to grow at the fastest CAGR during the forecast period.

How Artificial Intelligence (AI) is Changing the Vaccine Adjuvants Market?

The integration of artificial intelligence in the vaccine adjuvants market aids in the development of vaccine design, offering exceptional opportunities to accelerate the process. Algorithms such as machine learning and deep learning increase genomic data, protein structures, and immune systems interaction to predict antigenic epitopes, assess immunogenicity, and prioritize antigens for experimentation. AI in vaccine development emphasizes antigen selection, epitope prediction, adjuvant identification, and optimization strategies. The AI-driven point of view is used in the rational design of immunogens and the identification of new adjuvants with top-notch safety and efficacy outlines.

U.S. Vaccine Adjuvants Market Size and Growth 2024 to 2034

The U.S. vaccine adjuvants market size is evaluated at USD 510 million in 2024 and is projected to be worth around USD 650 million by 2034, growing at a CAGR of 2.41% from 2024 to 2034.

U.S. Vaccine Adjuvants Market Size 2024 to 2034

North America dominated the global vaccine adjuvants market in 2023. The dominance of this region is credited to the high commercial and research and development progress. A great investment by the U.S. government was made for the development, production, and purchase of vaccines. This public investment resulted in saving millions of lives and is crucial in the development of vaccine technology that also has the potential to address future pandemics and treat diseases beyond COVID-19.

  • The government of the United States granted contracts totalling USD 31.9 billion for vaccine development during COVID-19, among which USD 337 million was invested in pre-pandemic.

Vaccine Adjuvants Market Share, By Region, 2023 (%)

Middle East and Africa are anticipated to register significant growth in the vaccine adjuvants market during the forecast period. The expansion of this region is observed due to the rapid increase in the number of infectious diseases, rapid technological advancement, and rising healthcare costs, contributing to fuelling the market growth. The issues are addressed through the improvement in vaccine and vaccine adjuvant technology.

Market Overview

Adjuvants are components of vaccines that help to improve the proportion, and duration of the immune response to vaccination. Modernized adjuvants with improved properties including tailored humoral and cellular immune response, could provide a pathway for a new outbreak of innovative vaccines against existing and emerging pathogens. Currently, only a limited number of adjuvants are available for human use which are also licensed vaccines. Adjuvants have been used in vaccines for generations in the form of Aluminium salts, Aluminium Hydroxide, Aluminiun Phosphate, and Aluminon Potassium Sulphate. Nonetheless, the most effective of all is Aluminium salts.

Vaccine Adjuvants Market Growth Factors

  • Vaccine adjuvants have the potential to enhance immune potency to help the body produce a strong immune response in people receiving vaccines to protect against diseases.
  • Vaccine adjuvants make vaccines more effective by improving the efficacy of the existing vaccines. Along with that, high efficacy using less antigen could lead to short supply and high cost.
  • Reducing immunization scheduling is achieved with vaccine adjuvants reducing the amount of antigen per vaccine dose and the number of vaccination sessions. In some cases, they also increase the stability of the antigen components.
  • It helps in the development of new vaccines for treating allergies, autoimmune diseases, and cancer.

Market Scope

Report Coverage Details
Market Size by 2034 USD 2.18 Billion
Market Size in 2024 USD 1.73 Billion
Market Size in 2025 USD 1.77 Billion
Market Growth Rate from 2024 to 2034 CAGR of 2.33%
Largest Market North America
Base Year 2023
Forecast Period 2024 to 2034
Segments Covered Type, Application, Administrator, and Regions
Regions Covered North America, Europe, Asia-Pacific, Latin America and Middle East & Africa

Market Dynamics

Driver

Modernization of vaccine

Vaccines containing new adjuvant formulations are gaining traction in the vaccine adjuvants market, which leads to reaching advanced development, and licensing stages, and providing new tools to fulfill previous unmet clinical requirements. The perspective of vaccine developers and regulators towards new vaccine adjuvants depends predominantly on the contribution of the adjuvant and the importance of the vaccine. The advancement in the biotechnology sector has brought significant growth toward modern vaccines based on rationally designed combined antigens containing highly purified components with suitable safety profiles. It is essential for the vaccine and adjuvant developers to fully utilize the mechanism of adjuvant mode of action avoid using non-specific components in adjuvant creation and develop extensive data packages on the safety, tolerability, and efficacy of adjuvanted vaccines.

Restraint

Strict regulation

The vaccine adjuvants market comprises stringent regulation which acts as a hindrance to the growth of the market. These requirements consist of rigorous testing for safety and effectiveness and to meet the quality standard with new and already existing vaccines. Some agencies and authorities such as CDSCO, ICMR, MoHFW, Department of Health Research, and ACIP (Advisory Committee on Immunization Practice) work together to ensure the vaccine approval process is properly regulated. Additionally regular reviewing of their processes and procedures to address any potential gaps.

Opportunity

Synthetic components developments

Currently, adjuvants are formulated mostly of natural components. The vaccine adjuvants market is continuously evolving with novel developments. Synthetic components are expected to be used in the future. However, the existing approved adjuvants will also continue to be used as valuable assets. Synthetic molecules have the potential to become more effective activators. These molecules can be produced in bulk at a low cost. Before replacing natural components with synthetic ones, there will be concerns about safety and protective efficacy for the clinical trial.

Type Insights

The particulate segment captured the biggest share of the vaccine adjuvants market in 2023. The dominance of this segment is observed due to the immune system stimulation as it induces inflammatory responses. Several nanometers- to micrometer-sized particulates, such as particle matter 2.5 (PM2.5), sand dust, and diesel particles, cause pulmonary inflammation and allergic asthma. In contrast, these nanometer to micrometer-size particulates are utilized in the form of aluminum salts in vaccine adjuvants to enhance antibody response in humans and animals.

The pathogen segment shows notable growth in the vaccine adjuvants market during the forecast period. The expansion of this segment is experienced owing to vaccine adjuvants derived from pathogens such as bacterial or viral particles within the adjuvant which stimulate innate immune response, segmenting antigen presentation, and production of antibodies. This possesses the ability to mimic infectious agents while maintaining safety, offering a valuable asset in vaccine production.

Administration Insights

The intramuscular segment contributed the highest share in the vaccine adjuvants market in 2023. The intramuscular route of administration is gaining traction due to its increasing popularity among patients as it provides a more sustained release of the vaccine and improves the efficiency of the vaccine. Intramuscular injections are absorbed faster than subcutaneous injections, as the muscle tissues contain greater blood supple compared to tissues just under the skin.

The intradermal segment will show notable growth in the vaccine adjuvants market during the forecast period. The growth of the intradermal route of administration is noticed as it has the longest absorption time of all parenteral routes. It is used for sensitivity tests, such as tuberculosis, allergy, and local anesthesia tests. Delivery of vaccine antigens to the dermis human skin results is more efficient than injection into the muscle or subcutaneous tissue, which leads to a reduction in the volumes of antigen.

Application Insights

The infectious disease segment contributed the highest share in the vaccine adjuvants market in 2023. The dominance of this segment is observed as it improves the vaccine efficiency by enhancing the immune response to a vaccine’s antigens. As vaccines play a crucial role in limiting disease outbreaks and burdens, they are considered the best method for the long-term prevention of infectious diseases globally. The aging population is particularly at high risk due to the decline in immune function, which has potentially increased the risk of containing infectious diseases.

  • According to WHO, the top ten primary deaths in low-income countries are associated with infectious diseases such as malaria, influenza, tuberculosis, and HIV.

The cancer segment is anticipated to grow at the fastest CAGR in the vaccine adjuvants market during the forecast period. The expansion of this segment can be credited to the utilization of adjuvants in preventative vaccines and therapeutic vaccines to enhance immune response but also uses personalized tumor antigens. A therapeutic cancer vaccine has the ability to stop the tumor from growing or spreading, destroy the cancer cell after surgery or radiation therapy, and prevent cancer from returning.

  • In May 2024, scientists at Trinity College Dublin discovered a vaccine adjuvant called C100 which promotes potent antitumor immunity when injected directly into the tumor in an animal model.

Vaccine Adjuvants Market Companies

Vaccine Adjuvants Companies
  • GlaxoSmithKline plc
  • Agenus
  • Merck KGaA
  • InvivoGen
  • CSL Limited
  • Dynavax Technologies
  • Croda International PLC
  • OZ Biosciences
  • SEPPIC
  • SPI Pharma
  • Phibro Animal Health Corporation
  • Sanofi
  • Aphios Corporation
  • Avanti Polar Lipids, Inc.
  • Vertellus

Latest Announcements by Industry Leaders

  • In October 2024, Freek Snieders, CEO, of SPI Pharma said, “This partnership between SPI Pharma and Inimmune represents a powerful synergy of strengths. By bringing together SPI Pharma’s global commercial infrastructure with Inimmune’s cutting-edge expertise in biotechnology, we are poised to accelerate innovation and bring transformative solutions to the market. Together, we will enhance our capabilities to improve patient outcomes worldwide.”

Recent Developments

  • In October 2024, SPI Pharma, a global leader in biopharmaceutical excipient and adjuvant systems, and Inimmune, Corp., a fast-moving innovative biotechnology company, introduced their partnership to bring two adjuvant systems to the market. This partnership aims to launch a new adjuvant system at the World Vaccine Congress Europe, held in Barcelona.
  • In December 2024, Novavax Inc., a global company advancing protein-based vaccines with its Matrix-M™ adjuvant, announced it had signed a definitive agreement to sell its manufacturing facility in Bohumil, Czech Republic to Nova Nordisk for USD 200 million. 

Segments Covered in the Report

By Type

  • Pathogen
  • Adjuvant EMULSION
  • Particulate
  • Combination
  • Others

By Application

  • Infectious DISEASE
  • Cancer 
  • Others

By Administrator

  • Oral 
  • Intradermal
  • Intranasal
  • Intramuscular
  • Others

By Geography

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • Middle East and Africa

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Frequently Asked Questions

The global vaccine adjuvants market size is expected to grow from USD 1.73 billion in 2024 to USD 2.18 billion by 2034.

The vaccine adjuvants market is anticipated to grow at a CAGR of 2.33% between 2024 and 2034.

The major players operating in the vaccine adjuvants market are GlaxoSmithKline plc, Agenus, Merck KGaA, InvivoGen, CSL Limited, Dynavax Technologies, Croda International PLC, OZ Biosciences, SEPPIC, SPI Pharma, Phibro Animal Health Corporation, Sanofi, Aphios Corporation, Avanti Polar Lipids, Inc., Vertellus, and Others.

The driving factors of the vaccine adjuvants market is the it helps in the development of new vaccines for treating allergies, autoimmune diseases, and cancer.

North America region will lead the global vaccine adjuvants market during the forecast period 2024 to 2034.

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Kesiya Chacko, a dedicated and insightful author whose expertise spans Healthcare and Cross Domain industries. With a Master's degree in Microbiology, Kesiya has built a strong scientific foundation that allows her to approach market research with both depth and precision. With over 5+ years of experience in the Market Research Industry, Kesiya has worked across various sectors, developing a nuanced understanding

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