Liquid Biopsy Market Size, Share, and Trends 2024 to 2034

Liquid Biospy Market Size and Growth 2024 to 2033

The global liquid biopsy market size was valued at USD 5.39 billion in 2023 and is projected to surpass around USD 20.41 billion by 2033, poised to grow at a compound annual growth rate (CAGR) of 14.23% during the forecast period 2024 to 2033. North America liquid biopsy market was valued at USD 2.46 billion in 2023.

Liquid Biopsy Market Key Takeaways

• North America region has contributed 45.59% in 2023.
• By technology, the NGS segment hit revenue share of around 65.20% in 2023.
• By sample type, blood sample-based tests hit highest market share 67.59% in 2023.
• By usage, clinical segment has held revenue share of 72.17% in 2023.
• By biomaker, cell-free DNA segment has held revenue share of 47.87% in 2023.
• By product, kits & consumables has held revenue share of 53.12% in 2023.
• By indication, lung cancer has generated revenue share of 32.10% in 2023.
• By application, screening segment has accounted revenue share of 39.27% in 2023.

Liquid Biopsy Market Size in U.S. 2024 to 2033

The U.S. liquid biopsy market size was estimated at USD 1.85 billion in 2023 and is expected to hit around USD 6.62 billion by 2033 with a CAGR of 13.55% from 2024 to 2033.

Based on region, North America held the revenue share of 45.59% in 2023. This is mainly due to the increased adoption of the liquid biopsy in the North American region for the diagnosis of cancer. The rapidly growing cases of cancer in the huge market like US has resulted in the dominance of this region in the global liquid biopsy market. According to the American Cancer Society, in 2020, there were around 1.8 million new cancer cases were estimated in US.

Why Asia Pacific region will grow faster in the liquid biopsy market?

On the other hand, Asia Pacific is estimated to be the fastest-growing market during the forecast period. Asia Pacific is characterized by the increasing disposable income, increasing healthcare expenditure, rising awareness regarding the liquid biopsy techniques, and rising adoption of the advanced techniques in the hospitals, clinics, and diagnostic laboratories for the diagnosis. The growing penetration of hospitals and diagnostic centers in the region is expected to fuel the growth of the liquid biopsy market during the forthcoming years.

Clinical Trials Market Growth Factors

The global liquid biopsy market is primarily driven by the rising prevalence of cancer among the global population and rising awareness regarding the availability of different non-invasive treatments. As per the data provided by the International Agency for Research on Cancer in the GLOBOCAN 2020 estimates, around 19.3 million new cases of cancer and around 10 million deaths were reported due to cancer in 2020. The rising prevalence of breast cancer among the female population has made it the most common type of cancer diagnosed across the globe. In 2020, around 2.3 million new breast cancer cases were recorded, closely followed by the lungs cancer, colorectal cancer, and prostate cancer. Cancer is the second most leading cause of death across the globe, as per the World Health Organization. There are several benefits associated with the new liquid biopsy technique such as rapid results, low cost, early prognosis, overcoming tumor heterogeneity, low risk, and non-invasiveness. All these benefits of the liquid biopsy over the traditional diagnosis is fueling the adoption of the liquid biopsy among the patients across the globe, and is expected to significantly drive the demand during the forecast period.

The increased awareness about the cancer is boosting the liquid biopsy market growth as liquid biopsy technique can detect the cancer early, can monitor progression of tumor, and can assess clinical prognosis. Moreover, the proliferation of advanced technologies has boosted the demand for the non-invasive diagnosis and treatments that is expected to spur the demand for the liquid biopsy in the forthcoming years. The rising investments by the market players in the clinical trials for the development of innovative diagnostic solutions is exponentially contributing towards the market growth.

Liquid Biopsy Market Scope

Product Insights

The test/service segment was reached at $1,093.28 million in 2023. The growth can be accredited to the rising demand for the test/service.

The kits and consumables segment was reached at $2,867.07 million in 2023 and growing at a notable CAGR over the forecast period 2024 to 2033. The growth can be accredited to the rising demand for kit, due to inaccessibility of direct laboratories with infrastructure to undertake the liquid biopsy tests of most of the patients in need, the liquid biopsy market excessively relies on the distance collection of samples by transporting the diagnostics kits to the patient.

Global Liquid Biopsy Market Revenue, By Product, 2020-2023 (USD Million)

Technology Insights

Based on the technology, the next generation sequensing segment accounted highest revenue share in 2023. This is attributed to the higher efficiency of the NGS technology to detect even the lower frequency variants of cancer. The advancements in the NGS has resulted in the increased adoption of this technology as it can detect rare and novel mutations of cancer easily.

On the other hand, the PCR is estimated to be the most opportunistic segment during the forecast period. The adoption of PCR is rising owing to its rising uses for numerous purposes such as detecting fungal infections, bacterial infections, gene mapping, and other genomic applications. The quick and real-time diagnostic results provided by the PCR tests is accurate and it can guide the targeted therapies for the cancer treatment. The PCR is gaining immense popularity and is expected to witness a significant growth rate in the upcoming years.

Clinical Application Insights

The global liquid biopsy market (by clinical application) is currently being dominated by treatment monitoring. The growth can be accounted to the increased awareness and adoption of liquid biopsy tests for the early detection and treatment of cancer. The increase in the prevalence of the geriatric disease is witnessed, thus increasing the adoption of non-invasive biopsies.

The prognosis and recurrence monitoring segment will hit reach at notable CAGR over the forecast period. Some of the companies providing liquid biopsy techniques for the prognosis and reoccurrence monitoring of the disease are adaptive biotechnologies and pathway genomics, among others.

Indication Insights

Based on the application, the cancer segment dominated the global liquid biopsy market in 2023, in terms of revenue and is estimated to sustain its dominance during the forecast period. This is simply attributed to the increased adoption of the liquid biopsy techniques for the diagnosis of various types of cancer. The increased prevalence of cancer cases among the global population has boosted the growth of the cancer segment. According to the International Agency for Research on Cancer, the most prevalent types of cancer includes lungs cancer, breast cancer, prostate cancer, and colorectal cancer. The cancer cases across the globe is estimated to rise by 47% from 2020 to 2040, and the number of cancer cases are estimated to be 28.4 million by 2040 across the globe. Hence, this is expected to sustain the significance of this segment throughout the forecast period.

Global Liquid Biopsy Market Revenue, By Indication, 2020-2023 (USD Million)

Biomarker Insights

Based on the circulating biomarker, the circulating tumor cells segment dominated the market with the revenue share in 2022. The circulating tumor cells have gained rapid traction in the market as the liquid biopsy is considered as the most reliable method of detecting circulating tumor cells. Moreover, it facilitates in cancer prognosis, and can guide in the cancer therapeutics and monitor therapeutic regimens.

The circulating tumor cells was reached $1,857.08 million in 2023. The growth can be accredited to the rising demand for the CTCs biomarker for the early detection of cancer by performing non-invasive biopsies.

Circulating tumor cells or CTCs are the cells, which are being shed from the cancer tumor and are then circulated through the bloodstream. The advancements in the technologies, which help in the detection of CTCs from different body fluids have permitted the early detection of different types of cancers through minimal invasive techniques. The probable risk of cancer is mainly determined through the subsequent outgrowth of different tumor cells in new micro-environments of the body. Detecting CTCs and extracting required data still proves to be a tough approach due to their low concentrations in biological fluids. Their detection and characterization require highly sensitive instruments. The process of detecting CTCs includes enrichment of cell culture, purification, detection, and analysis of the sample.

The real-time liquid biopsy through CTCs analysis includes the collection of peripheral blood samples from the patient who is to be diagnosed. Later, the CTC enrichment is done by using both the physical properties (size, density, electric charges, and deformability) and the biological properties (cell surface protein expression and viability). After the enrichment of the sample, CTCs are needed to be identified from the blood mixture (mixture of leukocytes and CTCs). The detection can be carried out by making the use of protein-based or mRNA-based staining assays.

The developments in in-vivo techniques enable to bypass the limitation of the low concentration of CTCs. With the use of nano detectors, the samples with appreciable CTC concentration can be prepared for further analysis.

On the other hand, the circulating tumor DNA is expected to be the fastest-growing segment during the forecast period. The circulating tumor DNA helps in the early detection of the cancer and its mutation. It is most efficient in detection of the breast cancer. Therefore, the rising prevalence of breast cancer is expected to boost the growth of this segment. As per the GLOBOCAN report, breast cancer has surpassed the lungs cancer as the most diagnosed type of cancer across the globe in 2020.

The Cell-Free DNA segment was reached $2,583.65 million in 2023. The growth can be accredited to the rising demand for cfDNA kits due to easier isolation of cfDNA in the bloodstream owing to early detection of cancer by liquid biopsy test.

Global Liquid Biopsy Market Revenue, By Biomarkers, 2020-2023 (USD Million)

Key Companies & Market Share Insights

The market is moderately fragmented with the presence of several local companies. These market players are striving to gain higher market share by adopting strategies, such as investments, partnerships, and acquisitions & mergers. Companies are also spending on the development of improved products. Moreover, they are also focusing on maintaining competitive pricing.

In June 2021, Biocept Inc. and Quest Diagnostics collaborated to develop an advanced NGS testing technology especially for the lungs cancer patients.

The various developmental strategies like new product launches,partnerships, and collaboration fosters market growth and offers lucrative growth opportunities to the market players.

Liquid Biopsy Market Companies

• Bio-Rad Laboratories
• Biocept Inc.
• Guardant Health
• Illumina, Inc.
• F. Hoffmann-La Roche Ltd.
• Johnson & Johnson
• Laboratory Corporation of America Holdings
• MDxHealth SA
• QIAGEN N.V
• Thermo Fisher Scientific Inc.

Segments Covered in the Report

By Technology

• NGS
• PCR
• FISH
• Other

By Usage

• RUO
• Clinical

By Types of Sample

• Blood
• Urine
• Saliva
• CerebroSpinal Fluid

By Circulating Biomarker

• Circulating Tumor Cells
• Cell-free DNA
• Circulating Cell-Free RNA
• Exosomes and Extracellular Vesicles
• Others

By Products

• Test/Services
• Kits and Consumable
• Instruments

By Indication Type

• Lung Cancer
• Breast Cancer
• Prostate Cancer
• Colorectal Cancer
• Melanoma
• Other cancers
• Non-Oncology Disorders

By Clinical Application

• Treatment Monitoring
• Prognosis and Recurrence Monitoring
• Treatment Selection
• Diagnosis and Screening

By Geography

• North America
• U.S.
• Canada
• Europe
• U.K.
• Germany
• France
• Asia-Pacific
• China
• India
• Japan
• South Korea
• Malaysia
• Philippines
• Latin America
• Brazil
• Rest of Latin America
• Middle East & Africa (MEA)
• GCC
• North Africa
• South Africa
• Rest of the Middle East & Africa