The global gRNA market size was USD 503.74 million in 2023, calculated at USD 597.59 million in 2024 and is expected to reach around USD 2780.68 million by 2033, expanding at a CAGR of 18.63% from 2024 to 2033. The gRNA (guide RNA) applications include epigenetics, functional genomics, disease model studies, genome engineering, etc.
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The U.S. gRNA market size was valued at USD 190.41 million in 2023 and is expected to be worth around USD 1,068.41 million by 2033 with a noteworthy CAGR of 18.82% from 2024 to 2033.
North America dominated the global gRNA market in 2023. In North America, gRNA is highly used due to the number of key players investing in research and development to develop advanced and innovative products that help the growth of the market. The United States is the leading country in North American market growth.
Asia Pacific is expected to host the fastest growing gRNA market during the forecast period of 2024-2033. Developing healthcare infrastructure, the presence of certain target populations, rapid adoption of new technologies, and the presence of clinical necessities help the growth of the market in the region. China is the leading country for the growth of the market in Asia Pacific.
The gRNA market is a subset of the genomic industry that focuses on developing and producing gRNA molecules. gRNA molecules are made of a guide sequence, complementary to specific target sequences in the genome, and a scaffold sequence, which provides them with specificity and stability. They are used in many applications, including gene expression, gene editing, and gene regulation. gRNA in genetic therapies is used to cure, treat, and prevent specific inherited disorders like sickle cell disease, beta thalassemia, hemophilia, and cystic fibrosis.
gRNA technology is used in labs along with other reagents to perform many laboratory assays, which include gene expression studies, mutagenesis, development of mismatch assay for DNA modification, recombinant plasmid DNA, primers, and cell lines, cloning, whole genome sequencing, multiplex PCR, and classic PCR studies. It can be modified to improve the CRISPR system’s versatility, safety, specificity, and strength. These benefits help the growth of the gRNA market.
| Report Coverage | Details |
| Market Size by 2033 | USD 2780.68 Million |
| Market Size in 2023 | USD 503.74 Million |
| Market Size in 2024 | USD 597.59 Million |
| Market Growth Rate from 2024 to 2033 | CAGR of 18.63% |
| Largest Market | North America |
| Base Year | 2023 |
| Forecast Period | 2024 to 2033 |
| Segments Covered | Product & Service Type, gRNA Type, Application, End-use and Regions |
| Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Rising adoption of next-generation sequencing
gRNA is made from a scaffold sequence, essential for a user-defined Ì´20 nucleotide spacer and Cas-binding that defines the genomic target to be modified. Thus, by changing the gRNA target sequence, the genome target of the Cas protein can be changed. These factors help the growth of the gRNA market. Increasing R&D in genomics and proteomics leads to the development of the market. It is used in genomics and proteomics by improving the design and delivery of gRNA. These factors help to the growth of the market.
Disadvantages of gRNA
There are risks or disadvantages of the gRNA, including mismatches between the gRNA and target site, which may lead to off-target effects, depending on their positions and the number of mismatches. Designing numerous gRNA for every gene of interest may be necessary because the specificity and activity may be unpredictable. Structural elements of gRNA have an impact on cleavage efficiency. There is a requirement for structural analysis of each gRNA to verify that gRNA differs in its activities. These factors may restrict the growth of the gRNA market.
Research & development
There is an opportunity for future research & development in gRNA design. Implementing machine learning of artificial intelligence in gRNA design, including mathematical and algorithm models. This helps in data processing, prediction, classification, training, and feature extraction. Neural network advances for gRNA design help to evaluate the effectiveness of gRNA. Development of plants resistant to climate and disease, successful treatment of sickle cell anemia, and numerous experimental model systems, both traditional and novel. These factors help the growth of the gRNA market.
The products segment led the global gRNA market in 2023. The gRNA products include gRNA final products and gRNA final products in that gRNA synthesis kits and plasmid types are included. gRNA is used in many product applications like gene expression, gene editing, and gene regulation. gRNA is modified to enhance the CRISPR system’s versatility, safety, specificity, and stability. It has also been modified to improve the CRIPSR-CAS 9 system as a genome editing tool. gRNA synthesis kits are a fast assembly or a complete system for rapid synthesis of gRNA. These factors help to the growth of the product type segment and contribute to the development of the market.
The custom gRNA synthesis services segment is expected to grow significantly in the gRNA market during the forecast period. The custom gRNA synthesis helps to determine the efficiency and specificity of genome editing, purification of gRNA, quality control, and validation; it may target the desired genomic region or gene to avoid off-target effects, Cas enzyme binding, DNA repair mechanism, site-specific modification or cleavage, and target recognition. The application of custom gRNA synthesis services includes multi-scale delivery in plates or tubes, a wide range of modification options, and fast shipping, which helps the market grow. These factors help to grow the custom gRNA synthesis services type segment and contribute to the growth of the market.
The research-use segment dominated the gRNA market in 2023. In research use, gRNA is used due to its beneficial properties. gRNA is modified to improve its stability and protect against nuclease degradation by improving its efficiency. gRNA modified to improve the CRISPR system’s versatility, safety, specificity, and stability. gRNA is used in research laboratories with other reagents to perform a wide range of laboratory assays, which include cloning, whole-genome sequencing, multiplex PCR, classic PCR, development of recombinant plasmid DNA, primers, cell lines, gene expression, mismatch assay for DNA modification, and mutagenesis studies. These factors help to the growth of the research use segment and contribute to the growth of the market.
The GMP-grade segment is expected to gain a significant share of the gRNA market during the forecast period. GMP-grade gRNA is used in CRISPR-based therapeutic development or clinical trials. It helps to provide high-quality requirements for human clinical trials. GMP-grade reagents help microgram scale research/gRNA production to the gram scale gRNA production. GMP-grade products are made with active ingredients and high-quality raw materials, which are higher in purity or 98% purity. Ongoing monitoring of the manufacturing process's stability, packaging, and product quality, such as impurity or purity levels, and routine regulatory investigation are necessary. Implementation of GMP on the product may help to protect the company and consumers from negative effects. It helps to cut down waste or losses and avoid jail time, fines, and recalls. These factors help the growth of the GMP grade gRNA type segment and contribute to the growth of the market.
The genome engineering segment dominated the gRNA market in 2023 and is expected to grow at the fastest rate during the forecast period. In genome engineering, the CRISPR genome editing system permits users to design gRNA, which targets their DNA sequence of interest. The gRNA application in genome engineering technology is used in agriculture, biotechnology, infectious studies, therapeutics drugs, and medicines. The potential application of gRNA genome engineering in agriculture and human health helps to the growth of the market.
The pharmaceutical & biotechnology companies segment dominated the gRNA market in 2023. In pharmaceutical and biotechnology companies, gRNA is used due to its advantages, including allowing chemical modifications that help to prevent degradation of the CRISPR machinery by the response of intracellular immunity. For gene regulatory purposes, gRNA is used. The use of gRNA in pharmaceutical & biotechnology companies is due to their benefits like versatility, cost, accessibility, and simplicity, which help the growth of the segment. In the pharmaceutical sector, gene editing by using gRNA helps to treat, cure, or prevent specific inherited disorders like sickle cell disease, beta thalassemia, hemophilia, alpha-1 antitrypsin deficiency, and cystic fibrosis. They also may be used to treat infections, cancers, or HIV. These factors help the growth of the segment and contribute to the growth of the market.
The academic research institutes segment will grow at the fastest rate in the gRNA market over the forecast period. In academic research institutes, gRNA is used to accelerate research in diseases like mental illness and cancer. The use of gRNA in academic research institutes helps to perform laboratory assays, which include multiplex PCR, classic PCR, cloning, whole genome sequencing, development of recombinant plasmid DNA, primers, cell lines, gene expression, mutagenesis, and mismatch assay for DNA modification studies. These factors help the growth of the academic research institutes' end-use type segment and contribute to the growth of the market.
Segments Covered in the Report
By Product & Service Type
By gRNA Type
By Application
By End-use
By Geography
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