Single-Use Bioprocessing Connectors Market Size, Share and Trends 2025 to 2034

Single-Use Bioprocessing Connectors Market Size and Forecast 2025 to 2034

The global single-use bioprocessing connectors market size was estimated at USD 1.30 billion in 2024 and is predicted to increase from USD 1.51 billion in 2025 to approximately USD 5.64 billion by 2034, expanding at a CAGR of 15.80% from 2025 to 2034. Rising use of single-use bioprocessing systems is the key factor driving market growth. The surge in the production of biologics and biosimilars, coupled with innovations in the design of connectors, can fuel market growth further.

Single-Use Bioprocessing Connectors Market Key Takeaways

• North America led the market by holding the largest market share of 48% in 2024.
• Asia Pacific is expected to grow at the fastest CAGR of 17% over the forecast period.
• By product, the aseptic connectors segment held a major market share of 66% in 2024.
• By product, the conventional connectors segment is anticipated to grow at the fastest rate over the forecast period.
• By application, the upstream bioprocessing segment contributed the highest market share of 46% in 2024.
• By end use, the biopharmaceutical and pharmaceutical companies segment held the largest market share of 45% in 2024.
• By end use, the CMOs and CROs segment is projected to grow at the fastest rate during the forecast period.

Role of Artificial Intelligence (AI) in the Single-Use Bioprocessing Connectors Market

Artificial intelligence is poised to transform the single-use bioprocessing connectors market by improving manufacturing efficiency and ensuring high-grade standards integration in the production process can help to decrease human error, optimize production processes, and enhance the overall traceability of products. Furthermore, AI also streamlines production workflows by providing real-time monitoring, which improves regulatory compliance.

U.S. Single-Use Bioprocessing Connectors Market Size and Growth 2025 to 2034

The U.S. single-use bioprocessing connectors market size was exhibited at USD 500 million in 2024 and is projected to be worth around USD 2,200 million by 2034, growing at a CAGR of 15.96% from 2025 to 2034.

North America dominated the market in 2024. The dominance of the region can be attributed to the growth of the pharmaceutical and biotechnology sectors, coupled with the innovations in product offerings and increasing incidence of diseases like cancer. Furthermore, the growing funding and investments in drug discovery research play a key role in market expansion.

U.S. Single-Use Bioprocessing Connectors Market Trends

In the North American region, the U.S. led the market owing to the strong presence of large-scale production settings for biopharmaceuticals. This sector is regarded as the most R&D-intensive in the U.S., leading to market growth in the country further.

Asia Pacific is expected to grow at the fastest rate over the forecast period. The growth of the region can be credited to the expanding biopharmaceutical industry in emerging nations like China, Japan, and India. Increasing investments by the pharmaceutical and biotechnology companies can lead to market growth in the region further.

China Single-Use Bioprocessing Connectors Market Trends

China's market is rapidly growing due to the increasing demand for biopharmaceuticals. Many market players have been strengthening their production footprint in this country by forming new collaborations with China-based entities.

• In June 2024, WuXi Biologics announced the installation of three new sets of 5,000 L single-use bioreactors at its drug substance manufacturing facility in Hangzhou, China. This increases the manufacturing facility from 8,000L to 23,000L.

Europe's single-use bioprocessing connectors market is expected to grow at a lucrative rate over the foreseeable future. This growth is linked to the various summits and events addressing advancements in the field of bioprocessing in the region.

U.K. Single-Use Bioprocessing Connectors Market Trends

In the European region, the U.K. dominated the market due to the ongoing government investments to help market players and create an advantage against major global players. Contract service providers are increasingly investing in cutting-edge technologies, driving regional growth further.

Market Overview

Single-use bioprocessing is a process of producing biopharmaceuticals that utilize disposable, single-use equipment rather than conventional stainless-steel equipment. The single-use bioprocessing connectors market has many benefits, such as reduced setup time, decreased contamination risk, and enhanced flexibility. The single-use bioprocessing connectors reduce cost and control build-in system redundancy. It can also allow the manufacturing of multiple drugs within a single setting.

Single-Use Bioprocessing Connectors Market Growth Factors

• The growing demand for biologics and the biopharmaceutical industry is expected to boost single-use bioprocessing connectors market growth soon.
• The benefits of single-use bioprocessing over conventional production methods will likely propel market growth shortly.
• The increasing adoption of flexible biomanufacturing can contribute to the market expansion further.

Market Scope

Market Dynamics

Drivers

Increasing demand for biologics

The increasing need for biological therapeutics due to the growing prevalence of chronic disorders like autoimmune disorders and cancer fuels the market growth. Biologics such as monoclonal antibodies, vaccines, and antibodies are a key part of the pharmaceutical industry. In addition, they can offer targeted patient treatments, improving the efficacy of drug products.

• In February 2025, a Dover subsidiary launched the MicroCNX® Nano Series aseptic connectors, an innovative solution for cell and gene therapy (CGT) sterile processing. This industry-first product simplifies the connection process by allowing users to click connector halves together to create sterile flow paths, replacing traditional methods like biosafety cabinets and tube welding.

Restraint

Adverse environmental impact

The main hurdle for the market is the negative environmental impact caused because of the utilization of single-use plastics. The frequent use of plastics raises the carbon footprint which is hard to recycle. This poses a negative effect on the environment, hampering market growth. However, the leakage of the leachable and extractable from the plastic surface can be harmful to the patients.

Opportunity

Increasing preference for precision medicine

The single-use bioprocessing connectors market is creating lucrative opportunities in the future due to the rising preference for personalized medicines. Also, precision medicine is at the top of the manufacturing sector and drug development which has witnessed substantial growth in recent years due to an increase in cell and gene therapy. Furthermore, after producing a particular therapeutic, this equipment can be discarded, saving costs and time for manufacturers.

• In January 2025, Apollo and Leicester University launched a digital health and precision medicine center in India. The advanced research center will combine the resources and experience of both organizations to establish a global center for precision medicine and digital health.

Product Insights

The aseptic connectors segment dominated the single-use bioprocessing connectors market in 2024. The dominance of the segment can be attributed to the increasing use of aspects connectors in vaccine and biopharmaceutical production. These connectors are used in filtration, mixing, fluid transfer, and storage in these facilities. Additionally, they enable contamination-free and secure connections in single-use systems, enhancing process efficiency.

• In June 2024, Syntegon, a processing and packaging solutions company for the pharmaceutical, food, and medtech industries, unveiled its latest development. The new development is a patented Settle Plate Changer (SPC) for automated viable monitoring in the aseptic filling process. With this innovative solution, Syntegon will support customers in complying with the latest Annex 1 for both new and existing equipment.

The conventional connectors segment is anticipated to grow at the fastest rate over the forecast period. The growth of the segment can be credited to the cost-effectiveness of these connectors as compared to aseptic connectors. Conventional connectors are a type of single-use connectors that optimizes fluid transfer but cannot offer full aseptic assurance. They are commonly used in low contamination-sensitive applications.

Application Insights

The upstream bioprocessing segment led the single-use bioprocessing connectors market in 2024. The dominance of the segment can be linked to the advantages of upstream bioprocessing, like lowered operational costs, shortened timelines, and decreased cleaning needs. Moreover, this segment involves mixers, containers, disposable bioreactors, sampling systems, and probes/sensors.
End Use Insights

• In 2024, the biopharmaceutical and pharmaceutical companies segment led the single-use bioprocessing connectors market by holding the largest market share. The dominance of the segment is owing to the growing adoption of single-use bioprocessing connectors, the increasing need for cell & gene therapies, and individualized medicine in upstream & downstream processing.

The CMOs and CROs segment is projected to grow at the fastest rate during the forecast period. The growth of the segment is due to the increasing trend of outsourcing services to Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs), which has positively impacted the growth of the segment. Also, biopharmaceutical market players are seeking innovative technologies to improve the efficiency of their manufacturing process.

End Use Insights

In 2024, the biopharmaceutical and pharmaceutical companies segment led the single-use bioprocessing connectors market by holding the largest market share. The dominance of the segment is owing to the growing adoption of single-use bioprocessing connectors, the increasing need for cell & gene therapies, and individualized medicine in upstream & downstream processing.

The CMOs and CROs segment is projected to grow at the fastest rate during the forecast period. The growth of the segment is due to the increasing trend of outsourcing services to Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs), which has positively impacted the growth of the segment. Also, biopharmaceutical market players are seeking innovative technologies to improve the efficiency of their manufacturing process.

Single-Use Bioprocessing Connectors Market Companies

• Sartorius AG
• Merck KGaA
• Danaher
• Saint-Gobain
• Colder Products Company (Dover Corporation)
• Liquidyne Process Technologies, Inc.
• Foxx Life Sciences
• Watson-Marlow Fluid Technology Solutions

Latest Announcement by Market Leaders

In June 2025, Diatech Pharmacogenetics announced an expansion of its collaboration with Merck Serono Middle East Ltd., affiliates of Merck KGaA ("Merck"). The collaboration aims to improve patient access to RAS biomarker testing in the Middle East and Africa (MEA). Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10% of all cancer cases.
In February 2025, Danaher announced an investment partnership with Innovaccer Inc., a healthcare AI company, through its subsidiaries Danaher Diagnostics and Danaher Ventures. The partnership aims to enhance patient outcomes through digital and diagnostic solutions. Innovaccer has developed software solutions that create unified patient records to identify care gaps and at-risk patients. 

Recent Developments

In October 2024, Thermo Fisher Scientific announced the establishment of a Bioprocess Design Centre in Genome Valley, Hyderabad, in collaboration with the Government of Telangana. This facility will cover 10,000 square feet and is expected to commence operations in early 2025.
In April 2023, Merck announced the launch of Ultimus Single-Use Process Container Film to provide extreme durability and leak resistance for single-use assemblies used for bioprocessing liquid applications.

Segments Covered in the Report

By Product  

• Aseptic Connectors
• Conventional Connectors

By Application

• Upstream Bioprocessing
• Downstream Bioprocessing
• Fill-finish Operations

By End Use  

• Biopharmaceutical & Pharmaceutical Companies
• CROs & CMOs
• Academic & Research Institutes

By Geography

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa